The Azem palace of Hama, similar to the Azem palace in Damascus was also the residence of Assad Pasha Al Azem. He was governor of Hama, before he was transferred to Damascus in 1743.

It is often considered one of the strongest examples of Ottoman architecture and design. Unlike its Damascus twin, it has two courtyards one on each floor. The courtyard on the ground floor is decorated with trees planted to provide shade and has a fountain in the middle working as a cooling and refreshing system. At one end is a liwan with 3 sides where the residents used to sit. The second floor courtyard was purposely built to make use of breezes and the cool air.

The rooms inside are also beautifully decorated with both fountains and painted panels of birds and trees. There is a beautiful mosaic dating back to the 4th century AD in the room facing the riverside. This mosaic portrays a group of women playing musical instruments, and was found in the village of Mariamin (west of Homs). This mosaic is quite important, as it gives an idea of what musical instruments were like in those days. Other rooms also contain remains, as well as some Roman and early Christian remains in the lower courtyard.